Abstract #2016
Lipid and macromolecule suppression by double inversion recovery in metabolic mapping of the brain at 7T
Gilbert Hangel 1 , Bernhard Strasser 1 , Michal Povaan 1 , Stephan Gruber 1 , Marek Chmelik 1 , Siegfried Trattnig 1 , and Wolfgang Bogner 1
1
MCRE, Department of Biomedical Imaging and
Image-guided Therapy, Medical University of Vienna,
Wien, Vienna, Austria
This work presents a method of lipid and macromolecule
suppression using double inversion recovery (DIR) for
accelerated FID MRSI in the brain at 7T. DIR suppression
greatly reduces artifacts caused by extracranial lipids
and macromolecules, caused by fold-in due to parallel
imaging and non-optimal PSF. Two 10th-order WURST pulses
with 80 ms pulse duration and their timing were
optimized for 7T with a TI1/TI2 of 160/75 ms and a total
TR of 760 ms. Loss of metabolite SNR was quantified in
phantom measurements while volunteer measurements showed
in vivo feasibility and successful lipid artifact
reduction.
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