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Abstract #2013

7T MRS in Patients with 1.5T Normal Medically-Refractory Temporal Lobe Epilepsy

Simona Nikolova 1 , Jorge Burneo 2 , and Robert Bartha 3

1 Robarts Research Institute, London, ON, Canada, 2 Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada, 3 Medical Biophysics, University of Western Ontario, London, Ontario, Canada

The purpose of this preliminary 7T study was to characterize metabolite levels in the hippocampus of 1.5T- MRI negative temporal lobe epilepsy (TLE) patients. Eight MRI negative TLE patients (mean age 26 plus-or-minus sign 8 years) and eight healthy controls (mean age 32 plus-or-minus sign 8 years) were studied. Using short echo time MRS Semi-LASER spectroscopy at 7T significant differences were detected in hippocampal metabolite concentrations in patients with normal 1.5T MRI scans compared to healthy controls. The identification of structural and metabolic abnormalities using high field MRI could allow improved surgical selection of patients with temporal lobe epilepsy.

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