Abstract #2010
Dynamic Proton MRS Following the Infusion of [U-13C] Glucose to Measure Glutamate Metabolism in Temporal Lobe Epilepsy
Brenda Bartnik-Olson 1 , Daniel Ding 2 , John Howe 2 , Amul Shah 2 , and Travis Losey 3
1
Radiology, Loma Linda University Medical
Center, Loma Linda, CA, United States,
2
School
of Medicine, Loma Linda University, Loma Linda, CA,
United States,
3
Neurology,
Loma Linda University Medical Center, Loma Linda, CA,
United States
Several studies suggest that glucose metabolism and
glutamate-glutamine cycle activity may be impaired in
temporal lobe epilepsy (TLE). Glutamate is the primary
excitatory neurotransmitter in the brain and increased
levels of Glu have been reported in the epileptogenic
hippocampus. However, reduced Glu concentrations have
also been reported. In this study we used 1H MR
spectroscopy (MRS) to measure the Glu concentration and
rate of Glu synthesis in the medial temporal lobe of TLE
patients following an infusion of [U-13C] glucose. Our
findings show reduced Glu concentrations in the involved
mesial temporal lobe of TLE subjects while the rate of
Glu synthesis remained similar to healthy controls.
These findings suggest that reduced Glu concentrations
in the interictal state are not due to reduced oxidative
metabolism.
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