Chloride regulates fundamental physiological processes
which makes quantitative (
35
Cl)-MRI
interesting for biomedical research applications.
Partial volume effects caused by larger voxel sizes due
to a much lower MR-sensitivity and fast relaxation times
strongly reduce the accuracy of concentration
measurements. In this work partial volume correction was
applied on
35
Cl-data
of phantom and
in
vivo
measurements.
Quantification was performed using an external reference
cushion as well as B
0
- and B
1
-correction.
Good correction capability was seen for phantom
measurements and
in
vivo
application
allowed quantification of chlorine tissue concentration
in the human brain (CSF: 99
8,
brain matter: 27
3).
