Abstract #1998
Sodium (23Na) and UTE MRI for Detection of Nerve Cell Injuries in Concussed Patients: Preliminary Study
Yongxian Qian 1 and Luke C. Henry 2
1
Qian's Lab for MRI, General Labs Cloud LLC,
Pittsburgh, PA, United States,
2
Department
of Orthopaedic Surgery, University of Pittsburgh,
Pittsburgh, PA, United States
This work presents a preliminary study of a novel
methodology for noninvasive detection of membrane
disruption of nerve cells (neurons) and stretching tears
of nerve fibers (axons) in concussed patients. Sodium
(23Na) MRI was used to detect cell membrane disruption
through the change of intracellular sodium concentration
while high resolution (HR) ultrashort echo time (UTE)
proton (1H) MRI was used to detect axonal tears through
thin fissuring or tearing in brain tissues. Both imaging
modalities were performed on a clinical scanner at 3T.
The results showed promise of the proposed method for
the detection of nerve cell injuries in concussed
patients.
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