Abstract #1993
High resolution magic angle spinning 1H NMR spectroscopic investigation of listeria brainstem encephalitis in small ruminants: preliminary results
Christina Precht 1 , Galle Diserens 2 , Martina Vermathen 3 , Anna Oevermann 4 , Torsten Seuberlich 4 , Josiane Lauper 1 , Daniela Gorgas 1 , Chris Boesch 2 , and Peter Vermathen 2
1
Dept. of Clinical Veterinary Medicine,
University Bern, Bern, Bern, Switzerland,
2
Depts.
Radiology and Clinical Research, University Bern, Bern,
Switzerland,
3
Dept.
of Chemistry and Biochemistry, University Bern, Bern,
Switzerland,
4
Dept.
of Clinical Research and Veterinary Public Health,
University Bern, Bern, Switzerland
Listeria brainstem encephalitis is associated with high
mortality rates in ruminants and humans. The purpose of
our study was to investigate metabolic changes in
diseased small ruminants as a model for an inflammatory
disease. HR-MAS NMR spectroscopy identified clear
differences in the metabolic profile of biopsies from
the primarily affected brainstem. In the thalamus, which
commonly did show no or mild inflammatory infiltrates,
no clear separation but a trend towards a clustering of
the control and diseased group could be observed, and
may indicate that NMR spectroscopy is able to detect
metabolic changes before histopathologically observable
inflammatory infiltrates occur.
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