Abstract #1974
Test-retest quantitation of absolute metabolite concentrations with partial volume correction using different segmentation methods
Ahmad Seif Kanaan 1,2 , Andr Pampel 1 , Kirsten Mller-Vahl 2 , and Harald E. Mller 1
1
Nuclear Magnetic Resonance, Max Planck
Institute for Human Cognitive and Brain Sciences,
Leipzig, Sachsen, Germany,
2
Department
of Psychiatry, Social Psychiatry and Psychotherapy,
Medical School of Hannover, Hannover, Niedersachsen,
Germany
The quantitation of absolute metabolite concentrations
via Magnetic Resonance Spectroscopy using water as an
internal concentration standard, requires the accurate
determination of the compartmentation within the
localized region of interest. Previous work has shown
that different segmentation approaches yield different
estimates of metabolite levels in Grey matter [1]. In
this study, we investigated the test-retest reliability
of absolute metabolite quantitation using two commonly
used segmentation algorithms.
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