Abstract #1960
Six Fucose-α(1−2) Sugars and α-Fucose Assigned in Human Brain using In Vivo L-COSY
Scott Gregory Quadrelli 1 , Alexander Lin 2 , Saadallah Ramadan 1 , and Carolyn Mountford 1,3
1
Centre for MR in Health, The University of
Newcastle, Callaghan, NSW, Australia,
2
Center
for Clinical Spectroscopy, Brigham & Womens Hospital -
Harvard Medical School, Boston, MA, United States,
3
Center
for Clinical Spectroscopy, Brigham & Womens Hospital -
Harvard Medical School, Boston, NSW, Australia
A growing literature indicates that
Fucose7α(1−2)7galactose sugars are implicated in the
molecular mechanisms that underlie neuronal development,
learning, and memory in the human brain. An
understanding of the in-vivo roles played by these
terminal fucose residues, has been hampered by lack of
technology to non-invasively monitor their levels in the
human brain. We have implemented the in-vivo two
dimensional magnetic resonance spectroscopy technology
to examine the human brain in a three Tesla clinical MR
scanner and report that six Fucose-α(1−2)-galactose
residues, and free alpha-fucose, are available for
inspection. Fucose7α(1−3)-galactose residues cannot yet
be assigned using this technology as they resonate under
the water resonance. This new application offers an
unprecedented insight into the molecular mechanisms by
which fucosylated sugars contribute to neuronal
processes and how they alter during development, ageing
and disease.
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