Abstract #1955
2D Correlated MRS as a quantitative method to asses liver fatty acid composition of ob/ob mouse
Dimitri Martel 1 , Jean Baptiste Langlois 2 , Denis Friboulet 1 , Olivier Beuf 1 , and Helene Ratiney 1
1
CREATIS; CNRS UMR 5220; INSERM U1044;
Universit Lyon 1; INSA Lyon, Villeurbanne, France,
2
CERMEP-
Imagerie du Vivant, Bron, France
Localized Correlation Spectroscopy is used to assess
evolution of liver fatty acid in an ob/ob mice model at
two time points. A quantitative study is performed using
a dedicated time domain quantification procedure using a
simplified quantum mechanically basis set. This later is
constituted by the sub spin systems involved in the 2D
spectrum of triglycerides. Fatty acid Indexes and T2
values are obtained in agreement with expected model
evolution.Indexes and T2 values are obtained in
agreement with model evolution.
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