Abstract #1941
Quantum coherence spectroscopy to measure 1D 1 H-[ 13 C]-lipid signals
Lucas Lindeboom 1,2 , Robin A de Graaf 3 , Christine I Nabuurs 2,4 , Matthijs KC Hesselink 4 , Joachim E Wildberger 2 , Patrick Schrauwen 1 , and Vera B Schrauwen-Hinderling 1,2
1
Department of Human Biology, Maastricht
University Medical Center, Maastricht, Netherlands,
2
Department
of Radiology, Maastricht University Medical Center,
Maastricht, Netherlands,
3
Department
of Diagnostic Radiology, Magnetic Resonance Research
Center, Yale University School of Medicine, New Haven,
CT, United States,
4
Department
of Human Movement Sciences, Maastricht University
Medical Center, Maastricht, Netherlands
13
C-enriched lipid tracers are an excellent
candidate for in vivo MRS tracer studies on lipid
metabolism. Indirect detection of
13
C-lipid
signals can be useful to enhance the detection
sensitivity. Single shot methods are preferred in tissue
where movement artifacts and/or low fractional
enrichments are expected. We here compared the use of
modified versions of the conventional ge-HSQC and
ge-HMQC to get non phase distorted 1D 1H-[
13
C]-edited
spectra. We show that the ge-HSQC sequence yields the
highest signal and is therefore a candidate to be used
for studies following the incorporation of
13
C-lipid
tracers in human tissue.
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