Abstract #1935
Initial Evaluation of an MR-Hyperthermia Activated Thermosensitive Drug Delivery System
Matthew Tarasek 1 , Amanda Aleong 2,3 , Jinzi Zheng 2,3 , Yannan Dou 4 , Christine Allen 3,4 , David Jaffray 3,4 , Tom Foo 1 , and Desmond T.B. Yeo 1
1
MRI, GE Global Research, Niskayuna, NY,
United States,
2
Princess
Margaret Cancer Centre, Toronto, Canada,
3
Techna
Institute, University Health Network, Toronto, Canada,
4
University
of Toronto, Toronto, Canada
Current innovations in the field of advanced drug
delivery are focused on the development of new systems
that can (i) trigger drug release at the tumor sites,
(ii) avoid drug deposition in non-target tissues, and
(iii) allow for quantitative measurement of drug dose to
the target tissue. Here we report a pilot evaluation of
a novel MR image-guided radiofrequency (RF)
hyperthermia-mediated drug delivery platform. Results
indicate that the MR body coil provides adequate image
quality for monitoring drug release in the current
setup, despite its inherent limitations in image
acquisition speed and SNR when compared to surface-coil
arrays.
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