Abstract #1933
Non-invasive assessment of hyperthermic ultrasound enhanced tumor drug delivery with CE-MRI
Nadia Rose Ayat 1 , Rebecca Schur 1 , and Zheng-Rong Lu 1
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States
Utilizing mild hyperthermia (40-42C ) has the potential
to increase blood flow into tumors, and thus overcome
some of the barriers to drug delivery. This study
utilizes MRI to determine the effect of
ultrasound-induced mild hyperthermia on the uptake of a
paramagentically labeled polymer conjugate. The results
of this study show that contrast enhancement increased
two-fold upon the induction of hyperthermia in the tumor
periphery. A five-fold increase in contrast enhancement
was also seen in the tumor intersitium. This work
suggests that mild hyperthermia has the potential to
enhance the therapeutic efficacy of drugs in development
for cancer treatment.
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