Abstract #1924
Tracking and quantification of T-cells labelled with iron oxide nanoparticles using positive contrast
Jinjin Zhang 1 , Sidath C. Kumarapperuma 2 , Katie Hurley 3 , Hattie L. Ring 3 , and Michael Garwood 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota,
Minneapolis, MN, United States,
2
Department
of Medicinal Chemistry, University of Minnesota, MN,
United States,
3
Department
of Chemistry, University of Minnesota, MN, United States
Cell-based therapies have received much attention as
novel therapeutics for the treatment of cancer and
autoimmune disease. In this study, T-cells labeled with
superparamgnetic iron oxide nanoparticles (SPION) at
different concentrations were quantified using the SWIFT
Look-Locker T1 mapping method. The longitudinal
relaxation rate constant (R1) measured by SWIFT showed a
linear dependence on the concentration of SPION in
T-cells. These preliminary results indicate a potential
role for positive contrast from SWIFT as a means to
quantify the distribution of SPION-labeled cells,
provided the cells are incubated at a constant SPION
concentration.
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