Abstract #1896
Detecting Nanodiamonds With DNP
David E J Waddington 1,2 , Mathieu Sarracanie 1,3 , Huiliang Zhang 3,4 , David Reilly 2 , Ronald L Walsworth 3,4 , and Matthew S Rosen 1,3
1
MGH/A.A. Martinos Center for Biomedical
Imaging, Charlestown, MA, United States,
2
ARC
Centre of Excellence for Engineered Quantum Systems,
School of Physics, University of Sydney, Sydney, NSW,
Australia,
3
Department
of Physics, Harvard University, Cambridge, MA, United
States,
4
Harvard-Smithsonian
Center for Astrophysics, Cambridge, MA, United States
This work aims to develop a new bio-probe based on the
detection and tracking of nontoxic nanoparticles in
biological environments. We report the first DNP
enhancement of 1H in a nanodiamond/water solution at
very low magnetic field. Overhauser-enhanced MRI (OMRI)
utilizes the nuclear hyperpolarization of hydrogen to
detect paramagnetic species. A 1.36 times enhancement
of the 1H signal has been demonstrated in a 10%/wt
solution of 100 nm natural nanodiamonds (Microdiamant)
and DI water at 6.5 mT. This result will drive further
research into the use of OMRI methodologies as a means
of tracking nanoparticles in vivo.
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