Abstract #1878
19 F-Hyperpolarized Structures as Markers for the Improved Detection of Amyloid Plaques
Ute Bommerich 1,2 , Thomas Trantzschel 1 , Markus Plaumann 1 , Denise Lego 2 , Gerd Buntkowsky 3 , Grit Sauer 3 , Torsten Gutmann 3 , Joachim Bargon 4 , and Johannes Bernarding 1
1
Institute for Biometrics and Medical
Informatics, Otto von Guericke University Magdeburg,
Magdeburg, Saxony-Anhalt, Germany,
2
Special
Lab Non-invasive Brain Imaging, Leibniz Institute for
Neurobiology, Magdeburg, Saxony-Anhalt, Germany,
3
Eduard-Zintl-Institute
for Inorganic Chemistry, Technical University Darmstadt,
Hesse, Germany,
4
Institute
for Physical and Theoretical Chemistry, University Bonn,
North Rhine-Westphalia, Germany
Fluorinated bis(styryl)benzene derivatives can improve
the MR detection of amyloid plaques, that are supposed
to play an important role in the progression of
Alzheimers disease. These molecules enable
19
F-MRI
experiments with optimal contrast only restricted by the
concentration of the applied markers. An increase of
MR-sensitivity by orders of magnitude makes Parahydrogen
Induced Polarization (PHIP) a promising tool. It is
demonstrated that hyperpolarization of
19
F
nuclei in molecules that are structurally closely
related to amyloid markers is feasible. This leads to an
in-phase signal with improved intensity which could be
further increased by a field cycling step.
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