Abstract #1774
Frequency-Encoded MRI-CEST Agents Based on Paramagnetic Liposomes/RBC Aggregates
Giuseppe Ferrauto 1 , Enza Di Gregorio 1 , Simona Baroni 1 , and Silvio Aime 1
1
Molecular Biotechnology and Health Science,
Molecular Imaging Center-University of Torino (IT),
Torino, Italy
Positively charged paramagnetic liposomes have been
electrostatically bound to the membrane of RBCs. These
aggregates yield two CEST pools represented by liposomal
water protons (LipoCEST) and cytoplasmatic water protons
(ErythroCEST), respectively. When administrated In vivo
intravenously, these aggregates report about the
vascular volume ans the residual LipoCEST effect informs
about the presence of released liposomes in the tumor
region . the LipoCEST/RBC aggregates represent a new way
to label cells, a new route to improve the circulation
lifetime of the liposomes and a procedure to assess the
de-assembly of the aggregates and the accumulation of
the liposomes in the tumor.
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