Abstract #1766
GlucoCEST as method for early detection of renal allograft rejection
Annika Busch 1 , Dominik Kentrup 2 , Helga Pawelski 2 , Nirbhay N. Yadav 3,4 , Guanshu Liu 3,4 , Peter C.M. van Zijl 3,4 , Stefan Reuter 2 , and Verena Hoerr 1,5
1
Department of Clinical Radiology, University
Hospital Muenster, Muenster, Germany,
2
Department
of Medicine D - Experimental Nephrology, University
Hospital Muenster, Muenster, Germany,
3
Russel
H. Morgan Department of Radiology and Radiological
Science, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States,
4
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Research Institute, Baltimore, Maryland,
United States,
5
Institute
of Medical Microbiology, Jena University Hospital, Jena,
Germany
In this small animal study we implemented and validated
glucoCEST MRI for early detection and diagnosis of renal
allograft rejection in a rat model. By using an
optimized glucose infusion protocol which led to an
increased and constant blood glucose level over MR
measurement time, we obtained increased CEST contrast in
pelvis and cortex for renal allografts undergoing
rejection on day four post transplantation, compared to
native kidneys. Calculated CEST-intensity ratios of
transplanted and native kidneys were in good agreement
with data of previous PET studies.
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