Abstract #1755
Quantitative Assessment of Amide Proton Transfer (APT) and Nuclear Overhauser Enhancement (NOE) Imaging with Extrapolated Semi-solid Magnetization Transfer Reference (EMR) Signals - an Accurate and Straightforward Measurement Approach
Hye-Young Heo 1 , Yi Zhang 1 , Shanshan Jiang 1 , Dong-Hoon Lee 1 , and Jinyuan Zhou 1
1
Russell H Morgan Department of Radiology and
Radiological Science, Johns Hopkins University,
Baltimore, Maryland, United States
APT imaging is important molecular MRI technique that
detect endogenous mobile proteins in tissue, such as
those in the cytoplasm. To quantitatively assess APT and
NOE effects in vivo, a new fitting approach has been
introduced, which is based on the extrapolated
semi-solid MT model reference signals. The quantitative
APT and NOE signals were measured and compared with the
commonly used MTRasym(3.5ppm) in human glioma at 3
Tesla. The quantitative results showed that APT signals
were significantly higher in the glioma than in the
normal tissue and edema, and were the major contributor
to the APT-weighted image contrast.
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