Abstract #1745
Multi-parameter mapping of post-mortem lumbar spinal cord tissue in multiple sclerosis
Marco Battiston 1 , Marios C Yiannakas 1 , Jia Newcombe 2 , Claudia A M Wheeler-Kingshott 1 , and Rebecca S Samson 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
2
NeuroResource
Tissue Bank, UCL Institute of Neurology, London,
England, United Kingdom
Magnetisation Transfer imaging (MTI) methods are used to
probe the macromolecular content of tissue, and find
their main application in pathologies involving changes
in tissue myelin content, such as multiple sclerosis
(MS). Among MTI techniques, those defined as
semi-quantitative (i.e. model-free) are most commonly
used since they are easy to implement and less time
consuming, and therefore more clinically feasible. In
this work, a comparison between two semi-quantitative
indices, the Magnetisation Transfer Ratio (MTR) and MT
sat
,
calculated using the Multi-Parameter Mapping technique,
is performed both in healthy and MS
post-mortem
spinal
cord samples.
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