Abstract #1706
MR-based R2* and quantitative susceptibility mapping (QSM) of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry
Samir D. Sharma 1 , Bjoern P. Schoennagel 2 , Jin Yamamura 2 , Peter Nielsen 2 , Regine Grosse 2 , Hendrik Kooijman 3 , Roland Fischer 2,4 , Diego Hernando 1 , Gerhard Adam 2 , Peter Bannas 1 , and Scott R. Reeder 1,5
1
Radiology, University of Wisconsin, Madison,
WI, United States,
2
University
Medical Center Hamburg-Eppendorf, Hamburg, Germany,
3
Philips
Healthcare, Hamburg, Germany,
4
UCSF Benioff
Children's Hospital Oakland, Oakland, CA, United States,
5
Medical
Physics, University of Wisconsin, Madison, WI, United
States
Assessment of iron burden is essential for the
longitudinal monitoring and treatment of patients with
liver iron overload. The purpose of this work was to
investigate the relationship between MR-based R2* and
quantitative susceptibility mapping (QSM) with
SQUID-based biomagnetic liver susceptometry in patients
with suspected liver iron overload. Eleven patients were
recruited for this study from a population undergoing
cardiac MRI and liver susceptometry as part of their
regular iron monitoring. The correlation between R2* and
SQUID was found as R
2
=
0.88. Linear regression analysis between QSM and SQUID
yielded: slope = 0.630.09, y-intercept = -0.380.23, R
2
=
0.87.
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