Abstract #1702
Detection and Quantification of Microbleeds on Fixed Brain Specimens
Shunshan Li 1 , Mark J Fisher 2 , Ronald C Kim 3 , David Cribbs 4 , Mark J Hamamura 1 , Vitaly Vasilevko 4 , Annlia P Hill 2 , and Min-Ying Su 1
1
Tu&Yuen Center for Functional Onco-Imaging,
University of California, Irvine, CA, United States,
2
Department
of Neurology, University of California, Irvine, CA,
United States,
3
Department of Pathology,
University of California, Irvine, CA, United States,
4
Institute
for Memory Impairments and Neurological Disorders,
University of California, Irvine, CA, United States
It is difficult to confirm microbleeds found in in-vivo
MRI with pathological examination. Specimen imaging may
be used to verify the detected microbleeds and further
to correlate with disease progression of patients before
death. In this study 27 brains were imaged. A special
vacuum chamber with ultrasound probe was built to remove
bubbles on the surface of the specimen. Microbleeds were
found in 16/27=59% cases. Of 16 cases with confirmed
pathology, microbleeds were found in 3/9=33% normal
aging subjects, and in 3/5=60% Alzheimers disease
patients. An analysis software is being developed to
improve the detection sensitivity and size
quantification.
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