Abstract #1699
Oligodendrocytes and the role of iron in magnetic susceptibility driven frequency shifts in white matter
Tianyou Xu 1 , Sean Foxley 1 , and Karla Miller 1
1
Oxford Centre for Functional Magnetic
Resonance Imaging of the Brain, University of Oxford,
Oxford, Oxfordshire, United Kingdom
Previous works aimed at describing the relation between
susceptibility-driven properties of white matter and the
resultant MR signal have relied on models consisting of
only hollow cylinders, which simulate axons and their
myelin sheaths. While these models benefit from
simplicity, they do not capture the full diversity of
microstructures present in white matter. Other neuroglia,
with their distinct magnetic susceptibilities and
volumes, may also have significant influence modulating
the MR signal. We demonstrate that the incorporation of
iron-rich oligodendrocytes has a significant impact on
the underlying frequency distribution and MR signal by
virtue of their nontrivial volume fractions and magnetic
susceptibility.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
