Abstract #1695
Performing Dynamic Contrast-Enhanced MRI quality assurance for multi-centre trials using a multi-compartment phantom with physiological T1s
Neil Peter Jerome 1 , Vasia Papoutsaki 1 , James A d'Arcy 1 , Harold G Parkes 1 , Nandita deSouza 1 , Martin O Leach 1 , and David J Collins 1
1
Radiotherapy & Imaging, The Institute of
Cancer Research, Sutton, London, United Kingdom
The inclusion of Dynamic Contrast Enhanced MRI into
clinical trials, in particular those run across multiple
centres, requires that quality assurance be performed,
ensuring that functional parameters derived from
different scanners may be usefully combined and
compared. For DCE, the stability and noise
characteristics are useful metrics for comparison; we
present data from a multi-compartment test object with
physiological T1s that allow comparison of DCE protocols
with varying flip angles, as well as the same protocol
acquired at two separate scanners, and demonstrate the
usefulness of the test object for quality assurance of
DCE-MRI.
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