Abstract #1640
Expanding the treatment envelope for transcranial MR-guided focused ultrasound with a 256-element clinical transducer
Raag D Airan 1 , Gregory T Clement 2 , Ari Partanen 3 , Martin G Pomper 1 , and Keyvan Farahani 1,4
1
Radiology and Radiological Science, Johns
Hopkins Medical Institutions, Baltimore, Maryland,
United States,
2
Biomedical
Engineering, Cleveland Clinic Lerner Research Institute,
Cleveland, Ohio, United States,
3
Clinical
Science MR Therapy, Philips Healthcare, Andover,
Massachusetts, United States,
4
National
Cancer Institute, National Institutes of Health,
Bethesda, Maryland, United States
MR-guided high intensity focused ultrasound (MR-HIFU)
has demonstrated great promise for brain applications.
As currently implemented, MR-HIFU has a treatment
envelope limited to the center of the brain. We
demonstrate in silico that a 256-element
non-hemispherical clinical MR-HIFU transducer could
develop spatially compact sonication foci transcranially
in the brain, at clinically relevant locations in the
superficial cortex (superior temporal and inferior
frontal gyri) as well as near the skull base
(hippocampus, amygdala, nucleus accumbens, BA25, and
pons). These results are most relevant for applications
requiring lower sonication powers such as blood brain
barrier disruption and neuromodulation.
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