Abstract #1609
Diffusion-weighted Imaging using a Statistical Model as a Functional MRI of the Kidney: Preliminary Experience
Kentaro Yamada 1 , Hiroshi Shinmoto 1 , Seigo Ito 2 , Hiroo Kumagai 2 , Tatsumi Kaji 1 , and Koichi Oshio 3
1
Radiology, National Defense Medical College,
Tokorozawa, Saitama, Japan,
2
Nephrology
and Endocrinology, National Defense Medical College,
Saitama, Japan,
3
Diagnostic
Radiology, Keio University School of Medicine, Tokyo,
Japan
The purpose of this study was to evaluate the
appropriateness of diffusion-weighted imaging (DWI)
using a statistical model based on a truncated-Gaussian
distribution for diffusion signal decays of the kidney
and their correlation with renal function. Nineteen
patients with renal diseases and 13 healthy volunteers
were included. DWI was performed using five b-values (0,
500, 1000, 1500, and 2000). The statistical model
yielded a statistically better fit compared to the
mono-exponential model (P<0.01). Fraction of ADC<1.0 (%)
showed good correlation with renal function. This model
might aid in interpreting diffusion MR signals related
to histological changes in the kidney.
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