Abstract #1598
B0 inhomogeneity correction of T2* from fat-water MRI: application to a diet-induced obesity mouse model at 15.2T
Henry H. Ong 1,2 , Corey D. Webb 3 , Marnie L. Gruen 3 , Alyssa H. Hasty 3 , John C. Gore 1,2 , and E. Brian Welch 1,2
1
Vanderbilt University Institute of Imaging
Science, Nashville, TN, United States,
2
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
3
Molecular
Physiology and Biophysics, Vanderbilt University School
of Medicine, Nashville, TN, United States
Previously, we investigated the potential of T2*
estimated from quantitative fat-water MRI (FWMRI) as a
marker of adipose tissue inflammatory changes due to
adipocyte iron overload in an established diet-induced
obesity mouse model at 15.2T. Preliminary results
indicated presence of large background B0 variations
(50-250 Hz/mm) that could adversely affect T2* mapping.
Here, we implement a recently proposed B0 variation
correction of FWMRI data. Using a subset of our previous
data, we show feasibility of this correction method for
in vivo mouse data at 15.2T. The correction primarily
affects T2* and not fat-signal-fraction or
B0
in agreement with previous reports.
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