Abstract #1567
High non-linear diffusion fraction correlates with histological fibrosis in allograft kidneys
General Leung 1,2 , Nan Jiang 3 , Anthony A Sheen 1 , Serge Jothy 4 , Darren A Yuen 2,5 , and Anish Kirpalani 1,2
1
Medical Imaging, St. Michael's Hospital,
Toronto, Ontario, Canada,
2
Keenan
Research Centre, St Michael's Hospital, University of
Toronto, Toronto, Ontario, Canada,
3
Faculty
of Medicine, University of Toronto, Toronto, Canada,
4
Department
of Pathology, St. Michael's Hospital, Toronto, Ontario,
Canada,
5
Division
of Nephrology, St Michael's Hospital, Toronto, Ontario,
Canada
The signal acquired in a diffusion weighted sequence has
been shown to be sensitive to both perfusion and
diffusion components. We sought to find the degree to
which flow and microcirculation are present in
transplant kidneys by measuring the non-linear fraction
of the diffusion curve in 8 patients. We compared these
results to histopathology of the biopsy specimen. We
demonstrate an increased non-linear diffusion fraction
in patients with pathologically proven fibrosis. Further
investigation of the pathological specimens are
warranted to verify these findings.
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