Abstract #1537
Aortic Pulse Wave Velocity Measured using4D-Flow MRI in Patients with Portal Hypertension
Matthew R. Smith 1 , Alejandro Roldan-Alzate 1 , Oliver Wieben 1,2 , Scott B. Reeder 1,2 , and Christopher J. Francois 1
1
Radiology, University of Wisconsin, Madison,
WI, United States,
2
Medical
Physics, University of Wisconsin, Madison, WI, United
States
Diffuse liver disease, such as non-alcoholic fatty liver
disease (NAFLD), causes a generalizedpro-inflammatory
response that leads to increased risk of cardiovascular
disease. Aortic pulse wave velocity (PWV) is a biomarker
of vascular stiffeningthat can indicate increased
cardiovascular risk.We therefore hypothesized that
aortic PWV would be elevated in the setting of cirrhosis
and portal hypertension. 4D flow MRI was performed at 3T
in 11 patients with portal hypertension and 13 healthy
controls. Aortic PWV was calculated using the
time-to-foot (TTF) method and demonstrated statistically
significant differences between the two groups.
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