Abstract #1526
Simultaneous Acquisition Sequence for High Accuracy Whole Liver Perfusion Quantification(SAHA)
Jia Ning 1 , Bida Zhang 2 , Honsum Li 1 , Dan Zhu 1 , Feng Huang 2 , Shuo Chen 1 , Peter Koken 3 , Jouke Smink 4 , and Huijun Chen 1
1
Center for Biomedical Imaging Research,
Biomedical Engineering, School of Medicine, Tsinghua
University, Beijing, China,
2
Philips
Research China, Beijing, China,
3
Innovative
Technologies, Research Laboratories, Philips Technologie
GmbH, Hamburg, Germany,
4
Philips
Healthcare, MR Clinical Science, Best, Netherlands
Dynamic contrasted enhanced (DCE) MR imaging combined
with pharmacokinetic modeling, which can quantify the
perfusion and permeability of capillary in liver, is an
important technique in diagnosis for malignancy
detection, fibrosis stage estimation and hepatic
function evaluation [1]. DCE-MRI of liver requires high
temporal resolution for accurate arterial input function
(AIF) and portal venous input function (VIF). On the
other hand, high spatial resolution is also important
small lesion detection. However, it is hard to achieve
both high temporal resolution and spatial resolution at
the same time with enough SNR and coverage for whole
liver imaging. In this study, considering the AIF&VIF
are fast changing while the intensity of hepatic
parenchyma is slowly evolved, we propose a new DCE
acquisition method to acquire two 2D acquisitions for
high temporal resolution AIF and VIF, and a 3D
acquisition for high spatial resolution whole liver
imaging, simultaneously. In this interleaved acquisition
scheme, the proposed sequence can improve the accuracy
of pharmacokinetic analysis.
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