Abstract #1453
Longitudinal MRI of Progressive Pulmonary Fibrosis in a Transgenic, TGF-Alpha-Induced Mouse Model
Zackary I. Cleveland 1 , R. Scott Dunn 2 , Cynthia R. Davidson 3 , Jinbang Guo 1,4 , Jason C Woods 1,4 , and William D. Hardie 3
1
Center for Pulmonary Imaging Research,
Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, United States,
2
Imaging
Research Center, Department of Radiology, Cincinnati
Childrens Hospital Medical Center, OH, United States,
3
Division
of Pulmonary Medicine, Cincinnati Children's Hospital
Medical Center, OH, United States,
4
4)
Department of Physics, Washington University, St. Louis,
MO, United States
Idiopathic pulmonary fibrosis (IPF) is a poorly
understood, progressive, and fatal disease. Although,
mouse models are vital to IPF research, they typically
provide little temporal and spatial insight, and most
models fail to exhibit the non-inflammatory, progressive
fibrosis seen in clinical IPF. We report the first
imaging study of a non-inflammatory, progressive,
transgenic mouse model that mimics key biological and
temporal aspects of human IPF. In addition to
noninvasively visualizing the expected pattern of
fibrotic progression, this study revealed previously
unknown, dynamic tissue remodeling; demonstrating that
longitudinal MRI applied to relevant, preclinical models
can provide novel insights into IPF biology.
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