Abstract #1449
The relative contributions of the transition metals iron and manganese to T 1 and T 2 in white and gray matter
Kimberly L. Desmond 1,2 , Alia Al-Ebraheem 1 , Rafal Janik 2,3 , Wendy Oakden 2,4 , Jacek M. Kwiecien 5 , Wojciech Dabrowski 6 , Kalotina Geraki 7 , Greg J. Stanisz 2,4 , Michael Farquharson 1 , and Nicholas A. Bock 1
1
Medical Physics and Radiation Sciences,
McMaster University, Hamilton, Ontario, Canada,
2
Imaging
Research, Sunnybrook Research Institute, Toronto,
Ontario, Canada,
3
Medical Biophysics,
University of Toronto, Ontario, Canada,
4
Medical
Biophysics, University of Toronto, Toronto, Ontario,
Canada,
5
Pathology
& Molecular Medicine, McMaster University, Hamilton,
Ontario, Canada,
6
Anaesthesiology
and Intensive Therapy, Lublin Medical University,
Lublin, Poland,
7
Diamond
Light Source, Harwell Science and Innovation Campus,
Didcot, Oxfordshire, United Kingdom
In vivo
, quantitative, T
1
and
T
2
MRI
maps in gray and white matter of the severely
myelin-deficient Shaker rat and age-matched controls
were combined with metal maps of iron and manganese
obtained with synchrotron radiation X-Ray fluorescence
(XRF). Given the relaxivities of the transition metals
and their concentrations from XRF, it was found that a
substantial proportion of 1/T
1
was
due to the transition metals, and a much lesser
proportion of 1/T
2
. These results suggest
that T
1
and
T
2
could
be combined to disentangle the effects of myelin, Fe and
Mn in demyelinating diseases with suspected transition
metal involvement.
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