Abstract #1435
Test-retest reproducibility of BOLD-CVR measures in children using a computer-controlled CO 2 challenge
Jackie Leung 1 , Junseok Kim 2 , and Andrea Kassner 1,3
1
The Hospital for Sick Children, Toronto,
Ontario, Canada,
2
Institute
of Medical Science, University of Toronto, Toronto,
Ontario, Canada,
3
Medical
Imaging, University of Toronto, Toronto, Ontario, Canada
Cerebrovascular reactivity (CVR) is a form of a
cerebrovascular 'stress test' that offers insight into
the function of cerebrovasculature and has shown
applicability in the clinical assessment cerebrovascular
disease. Good reproducibility has previously been shown
in adults using blood-oxygen level-dependent (BOLD) MRI
measures in combination with a model-free prospective
end-tidal targeting (MPET) system. However,
reproducibility in children using this method has not
yet been established. Our study shows good within-day
and between-day reproducibility of BOLD-CVR measures
using the MPET that is comparable to the adult data.
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