Abstract #1417
Parametric response map (PRM) is a promising tool for the monitoring of post traumatic cerebral edema
Jules Grze 1,2 , Pierre Bouzat 1,2 , Jean-Franois Payen 1,2 , Emmanuel Barbier 2 , and Benjamin Lemasson 2
1
CHU Grenoble, Grenoble, France,
2
equipe
5, Grenoble Institute of Neuroscience, Grenoble, France
Post-traumatic cerebral edema in preclinical trials is
usually assessed using the Apparent diffusion
coefficient (ADC) measured by diffusion-weighted
magnetic resonance imaging. One generally estimates ADC
as the average value inside specific regions of interest
(ROI). Parametric response map (PRM), a voxel-based
analysis, is a tool to investigate spatially dispersed
changes of ADC over time. It allows to detect edematous
processes that are not necessarily detected by the mean
ADC value approach. PRM gives some spatial and
chronologic details that could distinguish different sub
population based on their ADC evolution. This technique
is promising in the field of traumatic brain injury.
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