Abstract #1398
Application of vector QSM for imaging multiple sclerosis lesions
Lijie Tu 1,2 , Cynthia Wisnieff 3 , Susan Gauthier 4 , David Pitt 5 , Yi Wang 1 , and Tian Liu 6
1
Radiology, Weill Cornell Medical College,
New York, NY, United States,
2
Applied
& Engineering Physics, Cornell University, Ithaca, NY,
United States,
3
Tufts
University, MA, United States,
4
Weill
Cornell Medical College, New York, NY, United States,
5
Neurology,
Yale University, New Haven, CT, United States,
6
Medimagemetric,
LLC, New York, NY, United States
To image multiple sclerosis lesions in white matter, a
tensor model may be needed to account for the
anisotropic susceptibility effect. In this study, we
applied a vector model for quantitative susceptibility
mapping in human brain, which only requires a single
scan. Comparison with histology confirmed that this
method is able to detect spatial changes of
susceptibility anisotropy. In vivo results suggest that
the susceptibility observed in multiple sclerosis
lesions arise primarily from iron instead of
demyelination.
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