Abstract #1394
Volumetric cervical spinal cord atrophy differs between younger and older onset relapsing-remitting multiple sclerosis (RRMS) and correlates with disability
Courtney A Bishop 1,2 , Emma McCarthy 3 , Richard Nicholas 2 , Lesley Honeyfield 4 , Paolo A Muraro 2,5 , Adam D Waldman 2,4 , and Rexford D Newbould 1,6
1
Imanova Centre for Imaging Sciences, London,
United Kingdom,
2
Division
of Brain Sciences, Imperial College London, London,
United Kingdom,
3
University
of Warwick, Coventry, United Kingdom,
4
Department
of Imaging, Imperial College Healthcare NHS Trust,
United Kingdom,
5
Department
of Clinical Neurosciences, Imperial College Healthcare
NHS Trust, United Kingdom,
6
Division
of Experimental Medicine, Imperial College London,
United Kingdom
T1-weighted volumes covering the entire cervical cord
were acquired on 162 RRMS patients with an average EDSS
of 3.5 and average disease duration of 4.4 years, but
separated as two age groups (mean difference of 13.8
years). Semi-automated delineation of the spinal cord
along the C2-C5 region revealed mean cross-sectional
area (CSA) measures were significantly smaller in the
older MS patients compared to the young (P=0.007) after
accounting for clinical covariates, and correlated
moderately well with disability (R=-0.37-0.38).
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