Abstract #1392
Resting State Fluctuation Amplitude Indicates Impaired Cerebrovascular Reactivity in Multiple Sclerosis
Mark J. Lowe 1 , Katherine A. Koenig 1 , Xiaopeng Zhou 1 , Wanyong Shin 1 , Robert Bermel 2 , Lael Stone 2 , and Micheal D. Phillips 1
1
Imaging Institute, Cleveland Clinic,
Cleveland, OH, United States,
2
Neurologic
Institute, Cleveland Clinic, Cleveland, OH, United
States
It is known that multiple sclerosis results in decreased
cerebral metabolic rate of oxygen and blood flow. Both
of these are critical elements in cerebrovascular
reactivity to neuronal activation. It has been shown
that resting state fluctuation amplitude (RSFA) can be a
surrogate to hypercapnic challenge as a measure of
cerebrovascular reactivity. We show that the correlation
between BOLD activation and RSFA is much weaker in MS
patients than in healthy controls, indicating that
cerebrovascular reactivity may be compromised in MS
populations.
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