Abstract #1381
Functional connectivity in nocturnal frontal lobe epilepsy: an fMRI resting state study
Stefania Evangelisti 1 , Laura Ludovica Gramegna 1 , Claudia Testa 1 , David Neil Manners 1 , Stefano Zanigni 1 , Claudio Bianchini 1 , Francesca Bisulli 2,3 , Laura Licchetta 2 , Ilaria Naldi 2 , Lorenzo Ferri 2 , Paolo Tinuper 2,3 , Caterina Tonon 1 , and Raffaele Lodi 1
1
Functional MR Unit, Policlinico
S.Orsola-Malpighi, Department of Biomedical and
NeuroMotor Sciences, University of Bologna, Bologna,
Italy,
2
Department
of Biomedical and NeuroMotor Sciences, University of
Bologna, Bologna, Italy,
3
IRCCS
Institute of Neurological Sciences of Bologna, Bologna,
Italy
Nocturnal frontal lobe epilepsy (NFLE) is a
heterogeneous disorder characterized by sleep-related
motor events of various semiology, intensity and
duration. The pathophysiology of the seizures has not
yet been completely elucidated. This study evaluated
fMRI resting state functional connectivity in NFLE
patients compared to controls. NFLE patients showed
greater functional connectivity between precuneus,
superior parietal lobe, primary and supplementary motor
areas, and thalamus. The thalamus is a structure
involved in non-REM spindles and the generation of
k-complexes. Our results may suggest an alteration of
the arousal regulatory system, with a particular
excitability of the cortex during non-REM sleep.
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