Abstract #1363
Alterations of cerebral white matter volume and metabolite concentration in patients with generalized anxiety disorder: A voxel-based morphometry and 1H-MRS
Chung-Man Moon 1 and Gwang-Woo Jeong 1,2
1
Radiology, Research Institute for Medical
Imaging, Gwangju, Gwangju, Korea,
2
Radiology,
Chonnam National University Hospital, Chonnam Natioanl
University Medical School, Gwangju, Korea
Generalized anxiety disorder (GAD) is characterized by
excessive, pervasive and uncontrollable anxiety in daily
life. Recent studies demonstrated that the symptoms of
GAD are associated with neural dysfunction related with
cognition and emotional regulation. However, it is
unclear how the white matter (WM) volume and cerebral
metabolites are associated with the typical symptoms of
GAD without other comorbid psychiatric disorders. The
purpose of this study was to investigate the
abnormalities in WM volumes and cerebral metabolite
concentrations in patients with GAD using the
voxel-based morphometry (VBM) and localized 1H-MR
spectroscopy (1H-MRS).
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