Abstract #1355
Reproducibility of metabolite measurements in patients with schizophrenia at 7T
Subechhya Pradhan 1 , Joseph S Gillen 1,2 , S. Andrea Wijtenburg 3 , Ashley D Harris 1 , Laura M Rowland 3 , and Peter B Barker 1,2
1
Russell H. Morgan Department of Radiology
and Radiological Science, Johns Hopkins University
School of Medicine, Baltimore, Maryland, United States,
2
Kennedy
Krieger Institute, Baltimore, Maryland, United States,
3
Department
of Psychiatry, Maryland Psychiatric Research Center,
University of Maryland School of Medicine, Baltimore,
Maryland, United States
MR spectroscopy is an important tool for the
non-invasive measurement of brain metabolite levels in
various neuropsychiatric disorders. Knowledge of the
reproducibility of metabolite measurements in patients
is important in studying metabolite changes due to
disease progression and/or treatment. In this study, we
assess the 1-week reproducibility of the metabolite
concentration measurements made at 7 Tesla using the
semi-LASER and STEAM sequences, in a cohort of subjects
with stable, chronic schizophrenia.
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