Abstract #1352
Neurostructural correlates of NCAN, a genome-wide significant risk gene for psychiatric disorders
Harald Kugel 1 , Udo Dannlowski 2,3 , Dominik Grotegerd 2 , Ronny Redlich 2 , Janina Suchy 2 , Nils Opel 2 , Thomas Suslow 2,4 , Carsten Konrad 3 , Patricia Ohrmann 2 , Jochen Bauer 2 , Tilo Kircher 3 , Axel Krug 3 , Andreas Jansen 3 , Bernhard T Baune 5 , Walter Heindel 1 , Katharina Domschke 6 , Volker Arolt 2 , Christa Hohoff 2 , Marcella Rietschel 7 , and Stephanie H Witt 7
1
Department of Clinical Radiology, University
of Mnster, Muenster, NRW, Germany,
2
Department
of Psychiatry, University of Mnster, Muenster, NRW,
Germany,
3
Department of Psychiatry, University
of Marburg, Marburg, HE, Germany,
4
Department
of Psychosomatic Medicine and Psychotherapy, University
of Leipzig, Leipzig, SN, Germany,
5
Discipline
of Psychiatry, University of Adelaide School of
Medicine, Adelaide, SA, Australia,
6
Department
of Psychiatry, University of Wrzburg, Wrzburg, BY,
Germany,
7
Department
of Genetic Epidemiology in Psychiatry, Central Institute
of Mental Health, Mannheim, BW, Germany
Neurocan (NCAN) rs1064395 genotype is associated with
psychiatric disorders as major depression,
schizophrenia, and bipolar disorder. In risk allele (A)
carriers, compared to carriers of the non-risk allele G,
voxel based morphometry (VBM) revealed reduced gray
matter volume in hippocampus and amygdala, in healthy
volunteers as well as in major depression patients. We
conclude that the increased risk for psychiatric
disorder may be mediated by structural deficits in
amygdala and hippocampus.
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