Abstract #1338
Coupling between the Salience Network and Default-mode Network Predicts Task-induced Deactivation through Regional Glutamate and GABA Concentrations
Hong Gu 1 , Yuzheng Hu 1 , Xi Chen 1 , and Yihong Yang 1
1
National Institute on Drug Abuse, NIH,
Baltimore, MD, United States
The coupling between the salience network (SN) and the
default mode network (assessed by the SN-PCC
connectivity) was negatively correlated with the
regional excitation and inhibition balance (expressed as
ratio of glutamate over GABA R_Glu/GABA) in PCC. Both of
the SN-PCC connectivity and the R_Glu/GABA predicted the
working memory task-induced deactivation in the PCC. The
mediation analysis showed the relationship between the
SN-PCC coupling and PCC deactivation was completely
mediated by the local balance of the excitation and
inhibition R_Glu/GABA.
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