Abstract #1317
Age Related Differences in Myelin Content Assessed Using Myelin Water Fraction Imaging
Muzamil Arshad 1,2 , Jeffrey A. Stanley 3 , and Naftali Raz 4,5
1
Psychiatry and Behavioral Neurosciences,
Wayne State University School of Medicine, Detroit, MI,
United States,
2
MD/PhD
Program, Wayne State University School of Medicine,
Detroit, MI, United States,
3
Psychiatry
and Behavioral Neurosciences, Wayne State University
School of Medicine, MI, United States,
4
Psychology,
Wayne State University, MI, United States,
5
Institute
of Gerontology, MI, United States
Age related reduction in myelin content of axons in
white matter tracts connecting association cortices has
been hypothesized as a potential substrate of age
related cognitive decline in normal healthy aging.
However, the most commonly used imaging methods to test
this hypothesis are not specific to myelin content.
Using multi-compartment T2 modeling we demonstrate
Myelin Water Fraction Imaging is sensitive to age
differences in myelin content in a healthy aging cohort.
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