Abstract #1308
Usefulness of LCModel Analysis with an Experimental Basis Set in Brain 1H-MRS at 3T
Hyeon-Man Baek 1,2 , Youngjae Jeon 1 , Jooyun Kim 1 , Mirim Bang 1 , Gyunggoo Cho 1 , and Chaejoon Cheong 1
1
Center for MR Research, Korea Basic Science
Institute, Ochang, Chungbuk, Korea,
2
Department
of Bio-Analytical Science, University of Science &
Technology, Yuseong-gu, Daejeon, Korea
In this study, in vivo 1H-MRS data and basis sets were
acquired in-house on the same scanner. To test the
performance of in-house basis sets, Cramer-Rao Lower
Bounds (CRLB) were calculated. We also investigate how
many and which metabolites can be reliably quantified in
human prefrontal cortex using short-echo time (TE)
1H-MRS at 3T. LCModel with in-house basis sets reliably
quantified 8 of 16 metabolites in the prefrontal cortex
of healthy subjects at 3T. However, GABA and Tau showed
relatively high CRLBs because these two peaks have
low-concentration.This means that LCModel using in-house
basis sets may be especially useful for short-TE and
metabolites characterized by strongly coupled
resonances, namely Ins, Glu, Gln, GSH, and Asp.
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