Abstract #1304
Cortical Modulation of Binaural Interaction on the Midbrain
Shu-Juan Fan 1,2 , Jevin W. Zhang 1,2 , Patrick P. Gao 1,2 , Dan H. Sanes 3 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
Kong SAR, China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong SAR, China,
3
Center
for Neural Science, New York University, New York, NY,
United States
Binaural interaction is important for recognizing
complex sound cues. This preliminary fMRI study probed
such cortical modulation effect in the major auditory
midbrain structure, inferior colliculus, in experimental
rodents with unilateral primary AC ablation. BOLD
response is significantly lower to binaural stimulation
than to uniaural stimulation, and such decrease was more
obvious in the right IC than in the left IC. These
results provide further evidence of descending
modulation of binaural interaction from AC. Further
experiments will be pursued in normal animals and other
auditory disorders to shine light on the understanding
of cortical modulation of binaural midbrain sound
processing.
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