Abstract #1272
Longitudinal Cortical Maturation in Typically Developing Infants and Children
Justin M Remer 1 , Douglas C Dean III 1,2 , Sara D'Arpino 1 , Elise Croteau-Chonka 1 , Holly Dirks 1 , and Sean C.L. Deoni 1,3
1
Advanced Baby Imaging Lab, School of
Engineering, Brown University, Providence, RI, United
States,
2
Waisman
Lab for Brain Imaging and Behavior, University of
Wisconsin, Madison, WI, United States,
3
Department
of Pediatric Radiology, Children's Hospital Colorado,
Aurora, CO, United States
Cortical development is a rapid and dynamic process that
has been shown been shown to be a predictive measure of
cognitive development in adolescents. Longitudinal
developmental trajectories of cortical thickness from
163 healthy, typically developing infants and children
were characterized using non-linear mixed effects
modeling and shown to exhibit both linear and non-linear
behavior. In addition, differential cortical development
based on early learning composite, a surrogate measure
of IQ, was observed in three specific brain regions. Our
results provide insight into the complexities behind
cortical maturation and provide an important foundation
for understanding typical cortical development.
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