Abstract #1253
Custom-Fit, 3D-Printed Marmoset Brain Holders for Comparison of Histology with MRI
Joseph Guy 1,2 , Pascal Sati 1 , Steven Jacobson 3 , Afonso C Silva 4 , and Daniel S Reich 1
1
Translational Neuroradiology Unit,
Neuroimmunology Branch, National Institute of Neurologic
Disorders and Stroke, Bethesda, MD, United States,
2
Department
of Biochemistry, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom,
3
Viral
Immunology Section, Neuroimmunology Branch, National
Institute of Neurologic Disorders and Stroke, Bethesda,
MD, United States,
4
Cerebral
Microcirculation Unit, Laboratory of Functional and
Molecular Imaging, National Institute of Neurologic
Disorders and Stroke, Bethesda, MD, United States
MRI and histology are two very different but uniquely
useful approaches to investigate diseases in cerebral
tissues. However, due to the inherent differences
between the methods (particularly image resolution), it
is difficult to combine them together to investigate
small-scale features/pathology. This can be overcome
with the use of custom-fit, 3D-printed cradles/slicers
that maintain alignment and orientation of brains
between MRI and tissue cutting. We applied this method
in marmoset brains and obtained a highly precise
comparison between in vivo MRI, ex vivo MRI, and
histology.
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