Abstract #1237
Canine MRI for X-linked myotubular myopathy
Joshua Park 1 , Martin Childers 2 , and Donghoon Lee 1
1
Radiology, University of Washington,
Seattle, WA, United States,
2
Rehabilitation
Medicine, University of Washington, Seattle, WA, United
States
Multi-parametric MRI was performed on a 3T MR human
scanner to monitor disease progression and responses to
adeno-associated viral (AAV) vector-medicated gene
therapy for dogs with X-linked myotubular myopathy
(XLMTM). We quantified T2 and apparent diffusion
coefficients along with 3 dimensional volume
measurements for the monitoring. Histopathology was also
conducted for tissues biopsized from the hindlimbs after
MRI for comparison. T2 relaxation, alongside diffusion
effect provides useful data towards the goal of
non-invasively monitoring the treatment of XLMTM. To our
knowledge, this is the first MRI study to assess the
disease and treatment responses for the canine model of
XLMTM.
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