Abstract #1215
Characterization of an Animal Model of Spinal Instability Using MR Elastography and Mechanical Testing
Ephraim I Ben-Abraham 1 , Jun Chen 2 , and Richard L Ehman 2
1
Mayo Graduate School, Mayo Clinic,
Rochester, Minnesota, United States,
2
Radiology,
Mayo Clinic, Rochester, MN, United States
Low back pain (LBP) is a very costly and prevalent
health disorder in the U.S. Spinal instability and
degenerative disc disease are two of the most common
causes of LBP. It is known that the stiffness of the
disc changes substantially with degeneration. MRE has
been demonstrated for estimating the shear stiffness of
the nucleus in the intervertebral disc in vitro. In this
study, we attempt to measure spinal instability in an in
vitro goat spine segment with induced disc degeneration
and mechanical destabilization. Our results suggest MRE
may be capable of detecting spinal instability.
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