Abstract #1128
In vivo high resolution multifrequency MR elastography of neuro tumors compared to single cell mechanical properties
Ingolf Sack 1 , Anatol Fritsch 2 , Steve Pawlizak 2 , Martin Reiss-Zimmermann 3 , Karl-Titus Hoffmann 3 , Felix Arlt 4 , Wolf Mller 5 , Jing Guo 1 , Jrgen Braun 6 , and Josef Ks 2
1
Radiology, Charit - Universittsmedizin
Berlin, Berlin, Berlin, Germany,
2
Physics
and Earth Sciences, University of Leipzig, Saxony,
Germany,
3
Department
of Neuroradiology, University Hospital, University of
Leipzig, Saxony, Germany,
4
Department
of Neurosurgery, University Hospital, University of
Leipzig, Saxony, Germany,
5
Department
of Neuropathology, University Hospital, University of
Leipzig, Saxony, Germany,
6
Department
of Medical Informatics, Charit - Universittsmedizin
Berlin, Berlin, Germany
This study aims to bridge the gap between micro and
macro scales of viscoelastic tissue properties in
tumors. High resolution MRE was applied within clinical
routine exams for measuring in-vivo viscoelastic
properties of 7 cerebral tumors of different entity.
Single cell viscoelastic properties of the same tumors
were measured after surgery by the optical stretcher. We
observed a significant correlation between in-vivo MRE
and single cell elasticity with marked softening in
high-WHO grade tumors. Thus, cellular mechanics is an
important marker for in-vivo tissue viscoelasticity by
which tumors can be staged in the future using MRE.
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