Abstract #1120
Perfusion correlated heterogeneity in NSCLC patient tumor glucose metabolism
Christopher Hensley 1 , Eunsook Jin 2,3 , Naama Lev-Cohain 4 , Qing Yuan 4 , Kemp Kernstine 5 , Craig Malloy 6,7 , Robert Lenkinski 6,7 , and Ralph Deberardinis 8,9
1
Children's Research Institute, University of
Texas Southwetern Medical Center, Dallas, Texas, United
States,
2
Advanced
Imaging Research Center, University of Texas Southwetern
Medical Center, Texas, United States,
3
Internal
Medicine, University of Texas Southwetern Medical
Center, Texas, United States,
4
Radiology,
University of Texas Southwetern Medical Center, Texas,
United States,
5
Cardiovascular
and Thoracic Surgery, University of Texas Southwetern
Medical Center, Texas, United States,
6
Advanced
Imaging Research Center, University of Texas Southwetern
Medical Center at Dallas, Texas, United States,
7
Radiology,
University of Texas Southwetern Medical Center at
Dallas, Texas, United States,
8
Children's
Research Institute, University of Texas Southwetern
Medical Center at Dallas, Texas, United States,
9
Pediatrics,
University of Texas Southwetern Medical Center at
Dallas, Texas, United States
Significant inter- and intratumoral heterogeneity in in
vivo glucose metabolism as assayed by [U-13C] glucose
infusions exist in non-small cell lung cancer (NSCLC)
patient primary tumors. We believe
microenvironment-based advanced imaging methods can be
used as pre-operative markers for intraoperative tumor
fragment sampling to begin to study the magnitude of
non-cell autonomous regulation of lung tumor metabolism.
We demonstrate this proof of concept with DCE-MRI to
assay the effects of heterogeneity in tumoral perfusion
on both oxidative and non-oxidative NSCLC patient tumor
glucose metabolism.
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